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Lewis et al. (2019) demonstrated histological and RNA-sequencing of synovial biopsies from a large cohort of early rheumatoid arthritis (RA) individuals to identify three histological pathotypes and reveal gene modules associated with disease severity and clinical response.
Full results and article of Molecular portrait of early Rheumatoid Arthritis identify clinical and treatment response phenotypes is published on nih.gov
Humby et al. (2019) carried out ultrasound guided synovial biopsy before and after DMARD treatment on patients with early RA.
Results and article of Synovial cellular and molecular signatures stratify clinical response to csDMARD therapy and predict radiographic progression in early rheumatoid arthritis patients is published on BMJ journals
Supporting publication by Gloria et al. (2019) investigated early RA patients by classifying them in 3 categories
Full results and article of Synovial tissue signatures enhance clinical classification and prognostic/treatment response algorithms in early inflammatory arthritis and predict requirement for subsequent biological therapy: results from the pathobiology of early arthritis cohort (PEAC) is published on nih.gov